IL6-STAT3 Signaling
Gene co-expression module in CD4⁺ T cells
| Category | Intercellular communication |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 22 genes have a known function matching the annotation |
Why this annotation
This module is anchored by STAT3 and IL6ST (gp130), the core IL-6 family signaling axis driving Th17/inflammatory CD4 T-cell responses, along with ARID5A (stabilizes IL6/STAT3 mRNA), AZIN1 (RNA editing target in STAT3 pathway). The positive correlation with inflammation in UC and CD supports an inflammatory signaling program. Other genes (CHD1, SFPQ, HNRNPU, MPHOSPH8, CDC40) are RNA processing/chromatin factors giving the module its moderate coherence, but the disease-relevant identity is STAT3/IL6ST signaling.
Genes
ARID5A, ARL6IP1, AZIN1, CCDC66, CDC40, CEMIP2, CHD1, CSNK1D, EIF4G2, GCC2, HERPUD1, HNRNPU, IL6ST, KPNA2, MAPK1IP1L, MPHOSPH8, PNPLA8, PPP2R2A, RAB21, SDCBP, SFPQ, STAT3
Most correlated modules
- DNA damage response · correlation 0.77
- T-cell quiescence regulation · correlation 0.67
- Cellular biosynthesis · correlation 0.63
- Transcription/RNA processing · correlation 0.60
- T cell Coinhibition · correlation 0.59
- Vesicle trafficking · correlation 0.58
- CD200 immunoregulation · correlation 0.58
- TCR early activation · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.