Cellular Housekeeping
Gene co-expression module in CD8⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes: YWHAE (14-3-3 epsilon, signal transduction scaffold), MRPL13 (mitochondrial ribosomal protein), ATP1B3 (Na/K-ATPase beta-3 subunit, ion transport), VDAC2 (mitochondrial outer membrane porin), PDAP1 (PDGFA-associated protein 1, cell growth), NUDC (nuclear distribution protein, cytoplasmic dynein), ZCRB1 (U12-type spliceosomal protein), PTBP1 (polypyrimidine tract-binding protein, RNA splicing/stability). This module combines mitochondrial (MRPL13, VDAC2), ion transport (ATP1B3), signaling scaffold (YWHAE), cytoskeletal/dynein (NUDC), and RNA processing (ZCRB1, PTBP1) components — a mixed housekeeping program with moderate mitochondrial flavor, consistent with its neighborhood among mitochondrial/housekeeping modules.
Genes
ATP1B3, MRPL13, NUDC, PDAP1, PTBP1, VDAC2, YWHAE, ZCRB1
Most correlated modules
- OxPhos & Proteasome · correlation 0.96
- Mitochondrial Housekeeping · correlation 0.96
- RNA & Redox Housekeeping · correlation 0.96
- Cellular Housekeeping · correlation 0.96
- Mitochondrial Metabolism · correlation 0.95
- Proteostasis Translation · correlation 0.94
- Complex I / OXPHOS · correlation 0.93
- Cellular Housekeeping · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.