OxPhos & Proteasome
Gene co-expression module in CD8⁺ T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include SLC25A3 (mitochondrial phosphate carrier), NDUFV2/NDUFC2 (Complex I subunits), PSMC5/PSMD7 (proteasome 19S regulatory subunits), CCT8 (chaperonin TRiC/CCT complex), SAP18 (Sin3A-associated protein, chromatin), PPM1G (PP2C phosphatase), and LSM8 (snRNP). The dominant theme is mitochondrial OXPHOS (Complex I), with proteasome and chaperone components. Moderate coherence reflects this mixed but related program. As neighbor to M70 and M80 (both mitochondrial), this module represents mitochondrial oxidative phosphorylation co-varying with protein quality control.
Genes
CCT8, ENY2, LSM8, NDUFC2, NDUFV2, PPM1G, PSMC5, PSMD7, SAP18, SLC25A3
Most correlated modules
- Complex I / OXPHOS · correlation 0.97
- Cellular Housekeeping · correlation 0.96
- Proteostasis Translation · correlation 0.96
- Cellular Housekeeping · correlation 0.95
- Proteasome Degradation · correlation 0.95
- Mitochondrial Housekeeping · correlation 0.94
- RNA & Redox Housekeeping · correlation 0.94
- RNA Processing Mixed · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.