NUDC — Nuclear distribution C, dynein complex regulator
NUDC belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NUDC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chaperonin Protein Folding Protein processing & ER | BANF1, CCT2, CCT3, CCT4, CCT5, CCT6A, EIF2S1, ILF2 +5 more | View in SCUBA |
| CD4⁺ T cells | Chaperone Proteostasis Protein processing & ER | BANF1, CCT3, CCT4, CCT5, FXR1, HNRNPH3, HSPB1, MAGOH +7 more | View in SCUBA |
| CD8⁺ T cells | Cellular Housekeeping Housekeeping | ATP1B3, MRPL13, PDAP1, PTBP1, VDAC2, YWHAE, ZCRB1 | View in SCUBA |
| Gamma-delta T cells | ER/Osmotic Stress Stress | ABHD3, DNAJA4, FKBP4, HIBCH, HSD17B7, HSPA4, HSPB1, MBNL2 +7 more | |
| Goblet cells | Proteostasis Housekeeping Housekeeping | ADRM1, EIF2S2, GNB2, MAGOHB, NME1, OAZ1, PARK7, PFDN2 +4 more | View in SCUBA |
| Hematopoietic progenitor cells | Chaperonin TRiC Complex Housekeeping | ARL2, CCDC85B, CCT2, CCT3, CCT5, CCT6A, GADD45GIP1, NDUFS5 +4 more | |
| Innate lymphoid cells | RNA-binding & Splicing RNA processing & translation | CALM1, DYNLL1, FUS, HNRNPA2B1, HNRNPAB, NCL, PPIG, SAP18 +4 more | View in SCUBA |
About the gene
| Chromosome | 1: 26900238-26946871 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.