PTBP1 — Polypyrimidine tract binding protein 1
PTBP1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTBP1's module in each cell type
About the gene
| Synonyms | HNRNP-I, HNRPI, pPTB, PTB, PTB-1, PTB2, PTB3, PTB4 |
|---|---|
| Chromosome | 19: 797075-812327 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Activator, Repressor, RNA-binding |
| Biological process | mRNA processing, mRNA splicing |
Function
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre- mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre- mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES- mediated translation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.