Cellular Housekeeping
Gene co-expression module in CD8⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include MRPL52 (mitochondrial ribosomal protein), VDAC1 (mitochondrial outer membrane channel), COX5A (Complex IV subunit), CHCHD2 (mitochondrial intermembrane space protein), alongside PSMB6/PSMC1 (proteasome subunits), SNRPB (spliceosome), PDIA6 (ER oxidoreductase), and RBX1/UBE2I (ubiquitin pathway). The module is uniform across subsets and shows moderate mean expression. The mix of mitochondrial, proteasomal, and ER components suggests a general housekeeping/cellular maintenance program rather than a specific biological state. The co-expression of these diverse housekeeping programs likely reflects low-level constitutive activity co-varying across cells at baseline metabolic activity.
Genes
CDC123, CHCHD2, COX5A, MRPL52, NUDT5, PDIA6, PSMB6, PSMC1, RBX1, SNRPB, UBE2I, VDAC1
Most correlated modules
- RNA Splicing Complex · correlation 0.97
- Proteasome Degradation · correlation 0.97
- Mitochondrial OxPhos · correlation 0.96
- Complex I / OXPHOS · correlation 0.96
- RNA & Redox Housekeeping · correlation 0.96
- Mitochondrial Housekeeping · correlation 0.96
- Cellular Housekeeping · correlation 0.96
- OxPhos & Proteasome · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.