Mitochondrial Housekeeping
Gene co-expression module in CD8⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include ELOC (elongin C, transcription elongation), MRPL57 (mitochondrial ribosomal protein), SNRPA1/SNRPF (spliceosomal snRNP components), STOML2 (mitochondrial inner membrane stomatin-like protein), NDUFB7 (Complex I subunit), AURKAIP1 (mitochondrial ribosome assembly), and RBM17 (RNA splicing factor). The module combines mitochondrial ribosome/OXPHOS genes with spliceosomal components, reflecting a general housekeeping transcriptional/mitochondrial maintenance program. As a topological neighbor of M70 and M71, all share mitochondrial and RNA processing components, supporting a cluster of constitutive housekeeping modules.
Genes
AURKAIP1, CCDC167, ELOC, ITGB1BP1, MRPL57, NDUFB7, PDCD5, RBM17, SNRPA1, SNRPF, STOML2
Most correlated modules
- Cellular Housekeeping · correlation 0.96
- Cellular Housekeeping · correlation 0.96
- Cellular Housekeeping · correlation 0.96
- Mitochondrial Metabolism · correlation 0.95
- General Housekeeping · correlation 0.95
- RNA & Redox Housekeeping · correlation 0.95
- Complex I / OXPHOS · correlation 0.94
- OxPhos & Proteasome · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.