RNA & Redox Housekeeping
Gene co-expression module in CD8⁺ T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes: SNRPE (spliceosomal Sm E protein), ANP32A (acidic nuclear phosphoprotein, chromatin/PP2A regulation), GGCT (gamma-glutamyl cyclotransferase, glutathione metabolism), LAGE3 (EKC/KEOPS complex, tRNA modification), CCT6A (chaperonin TRiC/CCT complex), NME1 (NDP kinase, metastasis suppressor), GLRX3 (glutaredoxin 3, redox), DPM2 (dolichol-phosphate mannose synthase), SERPINB1 (serine protease inhibitor), POLR2I (RNA Pol II subunit), COPRS (coordinator of PRMT5 and differentiation stimulator). The module combines spliceosomal (SNRPE, POLR2I), chaperone (CCT6A), redox (GGCT, GLRX3), tRNA modification (LAGE3), and chromatin (ANP32A, COPRS) components. Moderate coherence reflects this heterogeneous mix. As a neighbor of other mixed housekeeping modules (M70, M3, M22), this represents another constitutive cellular maintenance program.
Genes
ANP32A, C11orf58, CCT6A, COPRS, DPM2, GGCT, GLRX3, LAGE3, NME1, POLR2I, SERPINB1, SNRPE
Most correlated modules
- Cellular Housekeeping · correlation 0.96
- Cellular Housekeeping · correlation 0.96
- Mitochondrial Housekeeping · correlation 0.95
- RNA Splicing Complex · correlation 0.94
- OxPhos & Proteasome · correlation 0.94
- Complex I / OXPHOS · correlation 0.94
- Cellular Housekeeping · correlation 0.94
- Glycolysis Program · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.