Cellular Housekeeping
Gene co-expression module in CD8⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes include RANBP1 (Ran GTPase binding, nuclear transport), SLC25A5 (ANT2, mitochondrial ADP/ATP transporter), PSMC3 (26S proteasome ATPase), SNRPD1/SNRPG (spliceosomal Sm proteins), RPA3 (DNA replication/repair), FDPS (farnesyl pyrophosphate synthase, cholesterol/isoprenoid synthesis), ACAT2 (cholesterol esterification), UQCC2 (Complex III assembly), ACOT7 (acyl-CoA thioesterase), TALDO1 (pentose phosphate pathway), NUDT21 (RNA 3' cleavage), and RNASEH2C (DNA:RNA hybrid resolution). This is a mixed housekeeping module combining nuclear transport, mitochondrial metabolism, spliceosome, lipid metabolism, and DNA replication components — uniform across all subsets, suggesting constitutive low-level co-expression of core cellular maintenance genes.
Genes
ACAT2, ACOT7, CISD2, FDPS, NUDT21, PA2G4, PPIA, PSMC3, PSMG2, RANBP1, RNASEH2C, RPA3, SCCPDH, SLC25A5, SNRPD1, SNRPG, TALDO1, UQCC2
Most correlated modules
- Replication Licensing · correlation 0.96
- Mitochondrial Housekeeping · correlation 0.96
- General Housekeeping · correlation 0.96
- Mitochondrial Metabolism · correlation 0.96
- S-phase Progression · correlation 0.95
- Mitochondrial ETC/OxPhos · correlation 0.95
- Cellular Housekeeping · correlation 0.94
- RNA & Redox Housekeeping · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.