Proteostasis Translation
Gene co-expression module in CD8⁺ T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes: HNRNPM, HNRNPC, PCBP1, RBM8A (RNA binding/splicing), PSMD13, PSMD14 (proteasome 19S regulatory subunits), MDH1 (malate dehydrogenase, metabolism), CCT5, CCT7 (chaperonin TRiC/CCT complex subunits), RER1 (ER retention), BZW1 (translation), EIF2S2 (translation initiation). Strong coherence. This module mixes RNA processing (HNRNP members) with protein folding (CCT5/CCT7 chaperonins) and proteasome activity (PSMD13/14), suggesting a coupled protein biogenesis and quality control program. The CCT complex and proteasome subunits together indicate proteostasis. In the batch context, this module extends the RNA processing theme into protein synthesis and folding.
Genes
BZW1, CCT5, CCT7, EIF2S2, HNRNPC, HNRNPM, MDH1, PCBP1, PSMD13, PSMD14, RBM8A, RER1
Most correlated modules
- RNA Processing Mixed · correlation 0.96
- OxPhos & Proteasome · correlation 0.96
- Cellular Housekeeping · correlation 0.94
- Proteasome Degradation · correlation 0.94
- Nuclear RNA Splicing · correlation 0.94
- Metabolic Housekeeping · correlation 0.93
- Nucleocytoplasmic Transport · correlation 0.93
- Complex I / OXPHOS · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.