DUSP1 — Dual specificity phosphatase 1

DUSP1 belongs to a gene co-expression module in 16 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

DUSP1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	AP-1 Immediate Early BCR/AP1/NFKb pathway	BTG2, CD69, CD83, EIF1, FOS, FOSB, JUN, JUNB +7 more	View in SCUBA
CD4⁺ T cells	Immediate Early AP-1 TCR/AP1/NFKb pathway	BTG2, CD69, CDKN1A, EGR1, FOS, FOSB, IER2, IER5 +6 more	View in SCUBA
CD8⁺ T cells	TCR Complex Signaling TCR Signaling	ACAP1, ANXA1, CD37, CD3E, CITED2, EVL, LAPTM5, LCK +4 more	View in SCUBA
Endothelial	Shear Stress Response Stress	DNAJB1, EGR1, FOS, FOSB, HES1, HSP90AA1, HSPA1A, HSPA1B +11 more	View in SCUBA
Fibroblasts	NF-κB Immediate Early Inflammatory	ATF3, DNAJA1, HLA-E, HSPA8, IRF1, MAFF, NFKBIA, NFKBIZ +4 more	View in SCUBA
Gamma-delta T cells	TCR Early Activation TCR Signaling	BTG1, BTG2, CD69, CIRBP, CXCR4, EIF1, ETV3, FOS +15 more
Glial cells	Integrated Stress Response Stress	ATF3, CCNL1, DNAJA1, HSPA8, HSPH1, KLF4, MAFF, NR4A1 +2 more	View in SCUBA
Goblet cells	Immediate Early Gene chromatin regulation & transcription	BTG2, EGR1, FOS, FOSB, IER2, JUN, JUNB, JUND	View in SCUBA
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	CDKN1A, CSRNP1, DUSP2, DUSP6, ELL2, EZR, FOS, ICAM1 +26 more	View in SCUBA
Lymphatic endothelial	AP-1 Immediate Early Inflammation	EGR1, FOS, FOSB, HES1, HSPA8, IER2, JUN, JUNB +7 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more	View in SCUBA
Monocytes	AP-1 Inflammatory Activation Inflammatory	COQ7, FOS, IER2, JUN, JUNB, KCNE1, KLF6, NAIP +2 more	View in SCUBA
Mucosal-associated invariant T cell	Dissociation Stress Response Stress	EIF1, FOS, H3-3B, IER5, SAT1, SRSF3, SRSF7
Natural Killer cells	AP-1 Immediate Early activation	BTG1, CITED2, CXCR4, DUSP2, FOS, JUN, JUNB, KLF6 +1 more	View in SCUBA
Neutrophils	Immediate Early Response Stress	ADM, BTG2, EGR1, FOS, IER2, JUNB, ZFP36
Smooth muscle cells	Chaperonin heat-shock Stress	CYCS, HSPD1, HSPE1, ODC1, PABPC1, SLC25A25, SRSF3, UBE2D3	View in SCUBA

About the gene

Synonyms	CL100, HVH1, MKP-1, PTPN10
Chromosome	5: 172768096-172771195
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Enzymes, Predicted intracellular proteins
Molecular function	Hydrolase, Protein phosphatase
Biological process	Cell cycle, Stress response

Function

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.