Effector-Memory CD8
Gene co-expression module in CD8⁺ T cells
| Category | T cell maturation |
|---|---|
| Genes | 17 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 17 genes have a known function matching the annotation |
Why this annotation
Hub gene EOMES is a master transcription factor for effector and memory CD8 T cells. SH2D1A (SAP) is critical for NK and T cell signaling and is expressed in effector/memory CD8s. CD27 marks memory-competent T cells. CXCR3 is a chemokine receptor on effector-memory CD8 T cells mediating trafficking to inflamed tissues. CST7 (cystatin F) is expressed by cytotoxic and effector CD8 T cells. TRAT1 (TRIM) participates in TCR complex signaling. ITGB2 (CD18) is an integrin on activated lymphocytes. DUSP2 is a phosphatase modulating TCR signaling. CD44 is a canonical effector/memory T cell marker. TAGAP is a T cell activation GTPase-activating protein. SAMD3 and PYHIN1 are expressed in activated lymphocytes. TIMD4 and TSC22D1 are regulatory. HLA-E is expressed on activated T cells. CMC1 is a mitochondria-related gene. Together, this module strongly reflects an effector-memory CD8 T cell transcriptional program centered on EOMES.
Genes
CD27, CD44, CMC1, CST7, CXCR3, DUSP2, EOMES, F2R, HLA-E, ITGB2, PYHIN1, SAMD3, SH2D1A, TAGAP, TIMD4, TRAT1, TSC22D1
Most correlated modules
- Effector Memory CD8 · correlation 0.56
- Immediate Early Response · correlation 0.54
- Heat Shock Response · correlation 0.54
- TCR Complex Signaling · correlation 0.42
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.