TBC1D10C — TBC1 domain family member 10C
TBC1D10C belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TBC1D10C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell antigen presentation B cell maturation | APBB1IP, BMP2K, BTN2A2, CIITA, CYTH4, EVL, HHEX, MS4A1 +6 more | View in SCUBA |
| CD4⁺ T cells | Post-transcriptional regulation RNA processing | BCL11B, CCDC14, CHD2, CHD6, CREBZF, DDX39B, DNASE1, EVI2B +21 more | View in SCUBA |
| CD8⁺ T cells | TCR Complex Signaling TCR Signaling | ACAP1, ANXA1, CD37, CD3E, CITED2, DUSP1, EVL, LAPTM5 +4 more | View in SCUBA |
| Gamma-delta T cells | T Cell Homeostasis Housekeeping | ATP6V0E1, CALHM2, CNPY2, CSK, CSTB, DAD1, FERMT3, GTF2H5 +11 more | |
| Innate lymphoid cells | NK Cytotoxic Regulation Cytotoxicity | ARHGAP30, BIN2, CAPN12, CHD9, CLK1, CTSC, CYB5B, DDX27 +29 more | View in SCUBA |
| Mucosal-associated invariant T cell | Actin Cytoskeletal Dynamics Cytoskeletal | ACTB, ACTG1, CLIC1, CORO1A, CSK, CTSC, NHERF1, PPP1CA +2 more |
About the gene
| Synonyms | Carabin, EPI64C, FLJ00332 |
|---|---|
| Chromosome | 11: 67403915-67410089 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | GTPase activation |
Function
Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.