General Housekeeping
Gene co-expression module in CD8⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 14 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 14 of 14 genes have a known function matching the annotation |
Why this annotation
This module has strong coherence and uniform expression. Hub genes include ARPC5 (Arp2/3 complex, actin branching), BANF1 (barrier-to-autointegration factor, nuclear envelope/chromatin), RAN (GTPase regulating nuclear transport and mitosis), ANAPC11 (APC/C ubiquitin ligase, cell cycle), CALM3 (calmodulin, calcium signaling), YWHAH (14-3-3 protein, signaling scaffold), VDAC3 (mitochondrial voltage-dependent anion channel), COX8A (Complex IV, OxPhos), LSM4 (mRNA splicing/decapping), SRP9 (signal recognition particle, protein targeting), CARHSP1 (mRNA stability/stress), HMGN1 (chromatin remodeling), ANP32B (chromatin/apoptosis), SNRPC (spliceosome U1 snRNP). The combination of nuclear transport (RAN, BANF1), cell cycle (ANAPC11), cytoskeletal (ARPC5), signaling (CALM3, YWHAH), and housekeeping (COX8A, VDAC3, SRP9, LSM4) functions suggests a general housekeeping/cell maintenance module. Neighbor context (M28, M54, M19) supports a cluster of broadly expressed, low-specificity housekeeping programs. The module does not map cleanly to a single biological program; housekeeping best fits the overall composition.
Genes
ANAPC11, ANP32B, ARPC5, BANF1, CALM3, CARHSP1, COX8A, HMGN1, LSM4, RAN, SNRPC, SRP9, VDAC3, YWHAH
Most correlated modules
- Mitochondrial Metabolism · correlation 0.96
- Rho GTPase Cytoskeletal · correlation 0.96
- Cellular Housekeeping · correlation 0.96
- Mitotic Spindle · correlation 0.96
- Metabolic Housekeeping · correlation 0.96
- Mitochondrial ETC/OxPhos · correlation 0.96
- Replication Licensing · correlation 0.95
- Mitochondrial Housekeeping · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.