Epigenetic Chromatin Maintenance
Gene co-expression module in CD8⁺ T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes: BAZ1B (ISWI chromatin remodeling, Williams syndrome), HNRNPAB (RNA binding), SMC3, SMC1A (cohesin complex, chromosome cohesion), SUPT16H (FACT complex, histone chaperone), SUZ12 (PRC2 Polycomb repressor complex), NASP (histone chaperone), DNMT1 (DNA methyltransferase, epigenetic maintenance), DDX46 (RNA helicase/splicing), SET (histone chaperone/PP2A inhibitor), NOP56 (rRNA processing). Core coherence, mostly core/strong membership. This module is dominated by epigenetic regulators: chromatin remodeling (BAZ1B/ISWI, SUPT16H/FACT), Polycomb (SUZ12), cohesin (SMC1A/SMC3), DNA methylation (DNMT1), and histone chaperones (NASP, SET). This is a chromatin/epigenetic regulation module, distinct from the splicing-dominant neighbors, likely representing a DNA replication-coupled chromatin maintenance program.
Genes
BAZ1B, DDX46, DNMT1, HNRNPAB, NASP, NOP56, SET, SMC1A, SMC3, SUPT16H, SUZ12
Most correlated modules
- Nuclear RNA Splicing · correlation 0.96
- Pre-mRNA Splicing · correlation 0.89
- Replication Stress Checkpoint · correlation 0.88
- Nucleocytoplasmic Transport · correlation 0.87
- Chromatin RNA Processing · correlation 0.86
- S-phase Progression · correlation 0.85
- DNA Replication Fork · correlation 0.84
- S-phase Replication · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.