Mitosis & Cytokinesis
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 8 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
All 8 genes are classical M-phase/mitosis markers. SGO1 (shugoshin, protects centromeric cohesion); RACGAP1 (centralspindlin complex, cytokinesis); CKAP2L (cytoskeleton-associated, mitotic spindle); CDCA2 (repo-man, chromosome decondensation at mitotic exit); TOP2A (topoisomerase IIα, required for chromosome segregation, canonical proliferation marker); CEP55 (centrosomal protein, midbody, cytokinesis); NUSAP1 (nucleolar and spindle-associated protein, mitotic spindle stabilization); TACC3 (centrosomal, spindle assembly). This module is essentially a pure mitosis/cytokinesis module, distinguishable from M61 (kinetochore-attachment/spindle assembly checkpoint) by its emphasis on spindle organization and cytokinesis execution. Coherence is core with uniform expression across subsets consistent with a cycling cell minority.
Genes
CDCA2, CEP55, CKAP2L, NUSAP1, RACGAP1, SGO1, TACC3, TOP2A
Most correlated modules
- FOXM1-driven G2/M · correlation 0.99
- CDK1-Aurora Kinase Mitosis · correlation 0.99
- G2/M Cell Cycle · correlation 0.98
- Mitotic Spindle · correlation 0.98
- Spindle Bipolarity Cytokinesis · correlation 0.96
- Mitotic Spindle Assembly · correlation 0.95
- S-phase Chromatin Replication · correlation 0.95
- G1/S Entry Checkpoint · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.