S-phase Chromatin Replication
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes RAD21 (cohesin subunit, S/G2 phase), TMPO (lamina-associated, cell cycle-regulated nuclear envelope protein), NUCKS1 (chromatin remodeling, promotes cell cycle entry), NSD2 (histone methyltransferase, S-phase regulated), HP1BP3 (heterochromatin organization), ANP32E (histone chaperone, H2A.Z removal, linked to replication), UBE2S (APC/C-activating ubiquitin E2, mitotic exit), LBR (lamin B receptor, nuclear envelope reassembly post-mitosis), MIS18BP1 (centromere licensing/CENP-A deposition, G1/S), HDGF (nuclear growth factor, S-phase), TUBB4B (microtubule component), BRCA2 (homologous recombination/S-phase), CKAP2 (microtubule-associated, mitosis) all point to S-phase and G2/M chromatin/nuclear envelope regulation. This module represents a distinct but complementary phase of the cell cycle compared to M61 and M77, focusing on DNA replication licensing, chromatin organization, and cohesin-mediated sister chromatid cohesion.
Genes
ANP32E, BRCA2, CKAP2, HDGF, HP1BP3, LBR, MIS18BP1, NSD2, NUCKS1, RAD21, TMPO, TUBB4B, UBE2S
Most correlated modules
- Spindle Bipolarity Cytokinesis · correlation 0.95
- FOXM1-driven G2/M · correlation 0.95
- Mitosis & Cytokinesis · correlation 0.95
- Mitotic Spindle · correlation 0.93
- Mitotic Spindle Assembly · correlation 0.92
- CDK1-Aurora Kinase Mitosis · correlation 0.92
- G2/M Cell Cycle · correlation 0.91
- Mitotic Spindle · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.