G2/M Cell Cycle
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
All 10 hub genes are canonical cell cycle regulators acting at G2/M. PRC1 organizes the central spindle during cytokinesis; TTK (MPS1) is the spindle assembly checkpoint kinase; CDCA8 (Borealin) is a chromosomal passenger complex subunit; CDCA3 (Tome-1) triggers mitotic entry; CDC25C is the phosphatase that activates CDK1; CCNF (Cyclin F) coordinates late G2/M; HJURP is the CENPA chaperone; FBXO43 and DEPDC1B are mitotic regulators; FAM83D anchors the dynein-dynactin complex on mitotic spindles. The module is core-coherent with uniform low detection (~2.4%), consistent with a small cycling fraction in CD8 T cells. As a topological neighbor to M58 and M33 (both mitotic spindle/G2-M modules), the neighborhood strongly confirms a cell cycle G2/M identity.
Genes
CCNF, CDC25C, CDCA3, CDCA8, DEPDC1B, FAM83D, FBXO43, HJURP, PRC1, TTK
Most correlated modules
- Mitosis & Cytokinesis · correlation 0.98
- Mitotic Spindle · correlation 0.98
- CDK1-Aurora Kinase Mitosis · correlation 0.97
- FOXM1-driven G2/M · correlation 0.96
- Mitotic Kinase Cascade · correlation 0.95
- G1/S Entry Checkpoint · correlation 0.94
- Spindle Bipolarity Cytokinesis · correlation 0.93
- S-phase Chromatin Replication · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.