Metabolic Housekeeping
Gene co-expression module in CD8⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 9 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes ILF2 (interleukin enhancer binding factor 2, RNA binding/dsRNA sensing), SSNA1 (centrosome/microtubule stability), MRPL51 (mitochondrial ribosomal protein), TPM4 (tropomyosin, actin cytoskeleton), NDUFA2 (Complex I OxPhos subunit), COX17 (copper chaperone for cytochrome c oxidase), DAZAP1 (RNA binding protein), EIF4E (cap-dependent translation initiation), TADA3 (SAGA complex transcriptional coactivator). This is a mixed module with genes spanning mitochondrial function (MRPL51, NDUFA2, COX17), translation (EIF4E, DAZAP1), cytoskeleton (TPM4, SSNA1), and transcription (TADA3, ILF2). The strong coherence despite functional diversity is notable; it likely reflects housekeeping co-expression across metabolically active CD8 T cells. The mitochondrial/OxPhos theme (MRPL51, NDUFA2, COX17) is notable given the CD8 context. Given the mix, housekeeping is the most defensible label, with mitochondrial genes as a secondary signal.
Genes
COX17, DAZAP1, EIF4E, ILF2, MRPL51, NDUFA2, SSNA1, TADA3, TPM4
Most correlated modules
- General Housekeeping · correlation 0.96
- Proteasome Degradation · correlation 0.96
- Rho GTPase Cytoskeletal · correlation 0.95
- Cellular Housekeeping · correlation 0.94
- Proteostasis Translation · correlation 0.93
- Vesicle Trafficking · correlation 0.93
- Mitochondrial Housekeeping · correlation 0.92
- Cellular Housekeeping · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.