Mitotic Spindle
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
This is a tightly coherent (all genes 'core') module. Hub genes STMN1 (stathmin, microtubule destabilizer — canonical proliferating cell marker), TUBA1B and TUBB (alpha/beta tubulin, mitotic spindle), ZWINT (kinetochore component, required for mitotic checkpoint), CENPN (centromere protein, kinetochore assembly), LMNB1 (lamin B1, nuclear lamina, expressed in proliferating cells), DDX39A (RNA helicase involved in mRNA export and replication), ASF1B (histone chaperone, S-phase specific), DTYMK (thymidylate kinase, dNTP synthesis for DNA replication), GGH (gamma-glutamyl hydrolase, folate metabolism for nucleotide synthesis), HMGB2 and HMGN2 (high mobility group proteins, chromatin remodeling in proliferating cells). The combination of mitotic spindle (STMN1, TUBA1B, TUBB), kinetochore (ZWINT, CENPN), S-phase (ASF1B, DTYMK), and nuclear structure (LMNB1) genes gives an unambiguous cell cycle / proliferation signature. This is consistent with dividing CD8 T cells. Neighbor modules are also housekeeping/cytoskeletal, supporting a cluster of broadly expressed programs in metabolically active or cycling cells.
Genes
ASF1B, CENPN, DDX39A, DTYMK, GGH, HMGB2, HMGN2, LMNB1, STMN1, TUBA1B, TUBB, ZWINT
Most correlated modules
- Mitotic Spindle Assembly · correlation 0.97
- G2/M Checkpoint · correlation 0.96
- General Housekeeping · correlation 0.96
- Replication Licensing · correlation 0.96
- CDK1-Aurora Kinase Mitosis · correlation 0.95
- FOXM1-driven G2/M · correlation 0.94
- S-phase Progression · correlation 0.93
- Mitosis & Cytokinesis · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.