CDK1-Aurora Kinase Mitosis
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
UBE2C (ubiquitin E2 conjugating enzyme, APC/C substrate, mitotic exit); CCNA2 (cyclin A2, S and G2/M phase); CDK1 (master mitotic kinase); BIRC5 (survivin, chromosomal passenger complex, mitosis/apoptosis suppression); AURKB (Aurora kinase B, chromosomal passenger complex, spindle assembly checkpoint); CKS1B (CDK regulatory subunit, mitosis); KIF22 (kinesin, chromosome movement); MXD3 (Myc antagonist, promotes cell cycle in some contexts); MAD2L1 (spindle assembly checkpoint); CDKN3 (CDK phosphatase, mitotic regulation); KIFC1 (kinesin, bipolar spindle). CDK1/CCNA2/AURKB/MAD2L1 together define the spindle assembly checkpoint and CDK1 activation axis. This module is the CDK1/Aurora B/SAC module, complementing M84 (FOXM1-driven) and M77 (spindle/cytokinesis) with a focus on kinase-driven mitotic entry and checkpoint signaling.
Genes
AURKB, BIRC5, CCNA2, CDK1, CDKN3, CKS1B, KIF22, KIFC1, MAD2L1, MXD3, UBE2C
Most correlated modules
- Mitosis & Cytokinesis · correlation 0.99
- FOXM1-driven G2/M · correlation 0.98
- G2/M Cell Cycle · correlation 0.97
- Mitotic Spindle Assembly · correlation 0.96
- G1/S Entry Checkpoint · correlation 0.95
- Mitotic Spindle · correlation 0.95
- Mitotic Spindle · correlation 0.95
- Spindle Bipolarity Cytokinesis · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.