SCUBA

SRI — Sorcin

SRI belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SRI's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsInterferon response
Anti-viral		ACTN4, CAPZA1, CHMP4A, CHMP5, EFHD2, IL12RB1, LSP1, PARP14 +7 moreView in SCUBA
CD8⁺ T cellsER Protein Quality Control
Protein processing & ER		ARPC3, CALR, DYNLL1, MRPL47, PDIA3, PPIB, PSMA5, PSMB1 +3 moreView in SCUBA
EnterocytesMature colonocyte absorptive
Absorption		ADI1, BRI3, BTG1, CAMK2N1, CTSZ, FXYD3, GUCA2A, GUCA2B +9 moreView in SCUBA
Gamma-delta T cellsActin-based Motility
Cytoskeletal		APBB1IP, CD58, COMMD7, CORO1B, CTSD, EVL, FDFT1, HMOX2 +13 more
Goblet cellsActin Dynamics
Cytoskeletal		ABRACL, CD24, CFL1, MYL12A, NDUFB4, NDUFS5, OCIAD2, PIN4 +3 moreView in SCUBA
Hematopoietic progenitor cellsHematopoietic Progenitor Identity
Stemness		CD38, DAD1, HSH2D, HYAL3, ITGAE, KIT, MBOAT2, MTHFD2 +2 more
Innate lymphoid cellsILC-1 identity
Differentiation		ABRACL, BLOC1S1, C19orf53, CD52, DAD1, FUCA2, GMFG, HMGN3 +20 moreView in SCUBA
Lymphatic endothelialMitochondrial OxPhos Complex
Mitochondrial & OxPhos		ANAPC11, AP2M1, BRK1, LSM3, MRPL51, MRPS21, NDUFA12, NDUFAB1 +6 moreView in SCUBA
MacrophagesImmunoproteasome Induction
Inflammatory		CBR1, DAPP1, DYNLT1, EPSTI1, IFI35, LAP3, LGALS9, LYSMD2 +12 moreView in SCUBA

About the gene

Chromosome7: 88205115-88226993
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins

Function

Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.