RNA Splicing Complex
Gene co-expression module in CD8⁺ T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
This module has moderate coherence reflecting a mixed program. SF3B5 and SNU13 are spliceosomal components; EIF3I is a translation initiation factor; TIMM8B, MRPS6, NDUFS7 are mitochondrial; ATP6V0B/ATP6V1F are vacuolar ATPase subunits; PSMD4 is proteasomal; PRDX6, TXN, and PARK7 are redox/oxidative stress proteins. The RNA processing/splicing genes (SF3B5, SNU13, EIF3I) have the highest PageRank, suggesting RNA processing is the primary driver, with mitochondrial and redox components as secondary. As a neighbor to M27 (proteasome-heavy), the shared housekeeping character is consistent, but M8 distinctly captures the RNA processing machinery.
Genes
ATP6V0B, ATP6V1F, EIF3I, MRPS6, NDUFS7, PARK7, PRDX6, PSMD4, SF3B5, SNU13, TIMM8B, TXN
Most correlated modules
- Cellular Housekeeping · correlation 0.97
- Mitochondrial OxPhos · correlation 0.96
- Glycolysis Program · correlation 0.95
- RNA & Redox Housekeeping · correlation 0.94
- IFN-gamma Stress Response · correlation 0.94
- Complex I / OXPHOS · correlation 0.94
- Proteasome Degradation · correlation 0.93
- Rho GTPase Cytoskeletal · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.