Proteasome Degradation
Gene co-expression module in CD8⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes PSMB3, PSMB2, PSMD8 are core proteasome subunits; POLR2K and POLR2J are RNA Polymerase II subunits; NDUFB4 and ROMO1 are mitochondrial; CLTA is clathrin; HSBP1 is a heat shock binding protein; ARPP19 is a phosphoprotein regulator. The dominant theme is the ubiquitin-proteasome degradation machinery, uniformly expressed across all subsets consistent with constitutive housekeeping activity. Strong coherence supports a tight, single biological program centered on proteasomal protein degradation.
Genes
ARPP19, CLTA, GNG5, HSBP1, NDUFB4, POLR2J, POLR2K, PSMB2, PSMB3, PSMD8, ROMO1
Most correlated modules
- Cellular Housekeeping · correlation 0.97
- Mitochondrial OxPhos · correlation 0.96
- Metabolic Housekeeping · correlation 0.96
- Rho GTPase Cytoskeletal · correlation 0.96
- Complex I / OXPHOS · correlation 0.96
- OxPhos & Proteasome · correlation 0.95
- Mitochondrial Housekeeping · correlation 0.94
- General Housekeeping · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.