SNRPC — Small nuclear ribonucleoprotein polypeptide C
SNRPC belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SNRPC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Spliceosome snRNP RNA processing | CHCHD2, COX7B, GHITM, MAGOH, PPIA, RAN, SNRPB, SNRPD1 +4 more | View in SCUBA |
| CD4⁺ T cells | OxPhos & proteasome Mitochondrial & OxPhos | CCDC167, CLTA, COX17, COX5A, DBI, FKBP1A, FMNL1, GALM +10 more | View in SCUBA |
| CD8⁺ T cells | General Housekeeping Housekeeping | ANAPC11, ANP32B, ARPC5, BANF1, CALM3, CARHSP1, COX8A, HMGN1 +5 more | View in SCUBA |
| Endothelial | Nuclear Transport Housekeeping | AAMDC, ANP32B, CBX5, CDK4, CKAP4, COMMD4, COQ2, CSE1L +18 more | View in SCUBA |
| Gamma-delta T cells | snRNP Splicing RNA processing & translation | CHCHD2, DAZAP1, GAPDH, GIT1, GUK1, HDGF, ILF2, LAMTOR5 +16 more | |
| Innate lymphoid cells | ILC1 Cytoskeletal Metabolic Cytoskeleton & motility | ATP5F1B, ATXN10, CCT7, CD82, DNPH1, GADD45GIP1, HMGA1, MEA1 +14 more | View in SCUBA |
| Macrophages | Mitochondrial Biogenesis Mitochondrial & OxPhos | AIMP1, ATP5F1D, ATP5MC1, C1QBP, CCT2, CCT3, CCT7, CHCHD1 +38 more | View in SCUBA |
About the gene
| Synonyms | U1-C, Yhc1 |
|---|---|
| Chromosome | 6: 34757505-34773857 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Ribonucleoprotein, RNA-binding |
Function
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.