Rho GTPase Cytoskeletal
Gene co-expression module in CD8⁺ T cells
| Category | Cytoskeletal |
|---|---|
| Genes | 14 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes WDR1 (actin dynamics/cofilin cofactor), RAC1 (Rho GTPase, cytoskeletal remodeling), RHOA (Rho GTPase), and ARHGDIA (Rho GDP dissociation inhibitor) point to Rho GTPase-mediated cytoskeletal regulation. Supporting genes include PSMB7 and UBE2D2/UBE2A (ubiquitin-proteasome), PIN1 (prolyl isomerase involved in signaling), PPP4C (phosphatase), BUD31 (splicing), and POLR2G (RNA Pol II). The module is moderate coherence with several weak members, suggesting a mixed program. However, the dominant signal from RAC1, RHOA, ARHGDIA, and WDR1 anchors this as a cytoskeletal/Rho GTPase module, with secondary ubiquitin and RNA processing components as peripheral members. No specific T cell or CRC marker dominates. Neighbor modules (M59, M54, M19) are housekeeping/cell cycle programs, consistent with a broadly expressed cytoskeletal regulation module.
Genes
ARHGDIA, BUD31, CYB5B, MORF4L1, PIN1, POLR2G, PPP4C, PSMB7, RAC1, RHOA, SLC25A11, UBE2A, UBE2D2, WDR1
Most correlated modules
- Vesicle Trafficking · correlation 0.97
- General Housekeeping · correlation 0.96
- Proteasome Degradation · correlation 0.96
- Mitochondrial ETC/OxPhos · correlation 0.95
- Metabolic Housekeeping · correlation 0.95
- Cellular Housekeeping · correlation 0.95
- Glycolysis Program · correlation 0.94
- Mitochondrial Metabolism · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.