PSMC5 — Proteasome 26S subunit, ATPase 5
PSMC5 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PSMC5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | AP2M1, ATP5MF, ATP6V0B, AURKAIP1, BSG, CALM3, CLTB, CSNK2B +19 more | View in SCUBA |
| CD8⁺ T cells | OxPhos & Proteasome Mitochondrial & OxPhos | CCT8, ENY2, LSM8, NDUFC2, NDUFV2, PPM1G, PSMD7, SAP18 +1 more | View in SCUBA |
| Innate lymphoid cells | RNA Processing & Proteostasis RNA processing & translation | ATP5PD, CIRBP, COPS6, DPY30, MORF4L1, MYDGF, PDIA6, PNISR +5 more | View in SCUBA |
| Macrophages | Proteasome UPS Housekeeping | ACP1, ARPC5L, ATP6V1G1, AURKAIP1, C19orf53, CHMP2A, CIAO2B, CIB1 +31 more | View in SCUBA |
| Mucosal-associated invariant T cell | Antigen Processing Protein processing & ER | AQP3, ATP5MJ, CAPNS1, CCDC107, CTDNEP1, NCR3, NSA2, PHB2 +8 more | |
| Smooth muscle cells | OxPhos & proteasome Mitochondrial & OxPhos | CD151, CHCHD2, COX5B, EID1, NDUFA11, NDUFB2, NDUFB9, NEDD8 +8 more | View in SCUBA |
About the gene
| Synonyms | p45, p45/SUG, RPT6, S8, SUG-1, SUG1, TBP10, TRIP1 |
|---|---|
| Chromosome | 17: 63827152-63832026 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.