RNA Processing Mixed
Gene co-expression module in CD8⁺ T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include HNRNPH3, HNRNPA2B1, SRSF4, and RSRC2 (RNA-binding proteins/splicing regulators), alongside EZR (cytoskeletal linker), LCP1 (actin bundling), SLC3A2/SLC1A5 (amino acid transporters), TMBIM6 (anti-apoptotic ER protein), YWHAB (14-3-3 scaffold), MOB1A (Hippo signaling), and FUBP1/LRRFIP1 (nucleic acid binding). The module is moderate coherence with uniform expression across subsets, suggesting a general housekeeping/metabolic-splicing mixed program. Multiple HNRNP family members and SR proteins dominate, but cytoskeletal and transport genes are also present, indicating a broad post-transcriptional and cellular maintenance signature. In the context of the batch—where neighbors M4, M41, M5, M16 are all dominated by HNRNP/SR splicing factors—this module fits as a housekeeping RNA processing module, here with a slight cytoskeletal admixture.
Genes
AIP, CALM1, EZR, FUBP1, HNRNPA2B1, HNRNPH3, LCP1, LRRFIP1, MOB1A, RSRC2, SLC1A5, SLC3A2, SRSF4, STIP1, TMBIM6, TPM3, YWHAB
Most correlated modules
- Proteostasis Translation · correlation 0.96
- Nuclear RNA Splicing · correlation 0.95
- OxPhos & Proteasome · correlation 0.94
- Chromatin RNA Processing · correlation 0.93
- Nucleocytoplasmic Transport · correlation 0.93
- Pre-mRNA Splicing · correlation 0.91
- Actomyosin Motility · correlation 0.90
- ER Protein Quality Control · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.