TSPAN14 — Tetraspanin 14

TSPAN14 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TSPAN14's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	RNA & Chromatin Regulation RNA processing	ATRX, DCP2, DIP2A, HNRNPLL, KDM5B, NCOR1, OGDH, RIOK3 +7 more	View in SCUBA
CD8⁺ T cells	Gut Residence Trm Gut residence	CD96, FUT8, ITGAE, METTL8, MYO7A, NAB1, NAP1L4, PAG1 +4 more	View in SCUBA
Endothelial	TGF-beta ECM Remodeling ECM remodeling	ADAM10, APLP2, CCNDBP1, CYB5R3, DHRS3, EFEMP2, GNAS, HIPK2 +10 more	View in SCUBA
Gamma-delta T cells	γδ T Cell Identity T cell maturation	AGAP1, AGPAT4, C1orf21, CD226, CD47, GAS7, ITGA5, ITGAM +7 more
Lymphatic endothelial	Lymphatic Specification endothelial development	ARHGAP29, BOD1L1, CALD1, CLCN3, DECR1, GCC2, MINDY2, MPHOSPH8 +9 more	View in SCUBA
Macrophages	Sphingolipid Membrane Homeostasis Lipid metabolism	ACER3, AGPAT3, ARHGEF11, ATP2A2, C9orf72, CMIP, DMXL2, DOCK8 +12 more	View in SCUBA

About the gene

Synonyms	DC-TM4F2, MGC11352, TM4SF14
Chromosome	10: 80454265-80533124
Predicted location	Membrane
Essential gene	No
Protein class	Predicted membrane proteins, Transporters

Function

Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.