Proliferating CD8 T cell
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub gene AHI1 is involved in ciliogenesis and mTOR signaling. SQLE (squalene epoxidase) is a rate-limiting enzyme in cholesterol/sterol biosynthesis — a hallmark of proliferating and metabolically active cells. CDK6 is a cyclin-dependent kinase driving G1-S cell cycle progression. SLC7A5 (LAT1) is an amino acid transporter upregulated in proliferating and activated T cells, regulated by mTOR. GOLIM4 is a Golgi integral membrane protein associated with cell growth. TNS3 (tensin-3) is involved in integrin/adhesion signaling. TNIP3 negatively regulates NF-κB. VCAM1 (here at low expression, possibly regulatory context). ARL3 is a small GTPase in vesicle trafficking. The combination of CDK6, SQLE, SLC7A5 strongly points to a proliferating/metabolically activated T cell state. SQLE-driven cholesterol synthesis and CDK6-driven cell cycle are co-regulated in anabolic proliferating lymphocytes.
Genes
AHI1, ARL3, CDK6, GOLIM4, SLC7A5, SQLE, TNIP3, TNS3, VCAM1
Most correlated modules
- Gut Residence Trm · correlation 0.91
- TCR Activation & Modulation · correlation 0.86
- T Cell Activation · correlation 0.86
- Cytotoxic Exhausted CD8 · correlation 0.83
- Chromatin RNA Processing · correlation 0.83
- BATF-driven Activation · correlation 0.78
- Pre-mRNA Splicing · correlation 0.78
- TCR Proximal Signaling · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.