Chromatin RNA Processing
Gene co-expression module in CD8⁺ T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
Top hub genes: GNB1 (G-protein beta subunit), EIF4G2 (translation initiation), SFPQ (splicing/transcription), MTDH (metadherin, mRNA stability), CHD4 (chromatin remodeling NuRD complex), UBXN4 (ubiquitin regulatory), SRSF11 (splicing), ZNF207 (RNA processing), FLNA (actin filament). The module is strong coherence. SFPQ, SRSF11, ZNF207, and EIF4G2 are RNA processing/translation factors; CHD4 and UBXN4 point to chromatin/protein quality control. This is a mixed housekeeping module combining RNA processing and chromatin regulation, consistent with the broader batch neighborhood. GNB1 as top hub is unusual but has roles in signaling scaffolding. The module likely reflects general transcriptional/post-transcriptional housekeeping.
Genes
CHD4, EIF4G2, FLNA, GNB1, MTDH, SFPQ, SRSF11, UBXN4, ZNF207
Most correlated modules
- Pre-mRNA Splicing · correlation 0.94
- RNA Processing Mixed · correlation 0.93
- Actomyosin Motility · correlation 0.93
- Nuclear RNA Splicing · correlation 0.92
- Proteostasis Translation · correlation 0.90
- Nucleocytoplasmic Transport · correlation 0.86
- Epigenetic Chromatin Maintenance · correlation 0.86
- TCR Proximal Signaling · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.