RBPJ — Recombination signal binding protein for immunoglobulin kappa J region
RBPJ belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RBPJ's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR Complex Activation TCR/AP1/NFKb pathway | ABHD17A, ACTR3, C1GALT1, CD2, CD3D, CD3E, CD3G, CD81 +14 more | View in SCUBA |
| CD8⁺ T cells | Gut Residence Trm Gut residence | CD96, FUT8, ITGAE, METTL8, MYO7A, NAB1, NAP1L4, PAG1 +4 more | View in SCUBA |
| Fibroblasts | Notch Fibroblast Activation Developmental | CORO1C, DIXDC1, DSTN, FHL1, MRGPRF, PDLIM5, SH3BGRL, TCEAL3 +2 more | View in SCUBA |
| Goblet cells | RNA Decay Processing RNA processing & translation | CCNI, ILF2, RSL24D1, SRSF3, SYNCRIP, UBE2I, UBE2R2, XRCC5 +2 more | View in SCUBA |
| Innate lymphoid cells | ILC Survival Residency Gut residency | ARID4B, BAZ1A, BCL2A1, CD44, CSF2, CTSH, CXCL8, DUSP4 +25 more | View in SCUBA |
| Smooth muscle cells | Notch-TGFbeta Signaling Development | AHI1, CD81, CD9, CPED1, EDIL3, FHL1, GSN, JUND +3 more | View in SCUBA |
About the gene
| Synonyms | CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH |
|---|---|
| Chromosome | 4: 26163455-26435131 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Repressor |
| Biological process | Host-virus interaction, Notch signaling pathway, Transcription, Transcription regulation |
Function
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.