Oxidative Stress Survival
Gene co-expression module in Hematopoietic progenitor cells
| Category | Stress |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
SOD2 (manganese superoxide dismutase) is the primary mitochondrial antioxidant enzyme and a hallmark of oxidative stress response. SH3BGRL (SH3 domain-binding glutamic acid-rich-like protein) has thioredoxin-like redox activity. PIM1 is a pro-survival serine/threonine kinase expressed in hematopoietic cells under cytokine stimulation, protecting against apoptosis. GMPR (guanosine monophosphate reductase) is involved in nucleotide metabolism, expressed during erythroid differentiation. TAFA2 is a chemokine-like factor. The SOD2/SH3BGRL/PIM1 axis points to a mitochondrial oxidative stress and survival signaling program active in hematopoietic progenitors.
Genes
GMPR, KIFAP3, PIM1, RIPOR3, SH3BGRL, SOD2, STON2, TAFA2
Most correlated modules
- Erythro-Megakaryocytic Development · correlation 0.90
- HSC Stemness Program · correlation 0.88
- Erythroid Differentiation · correlation 0.87
- Erythroid Progenitor Program · correlation 0.85
- General Metabolic Housekeeping · correlation 0.82
- Replication Stress Response · correlation 0.82
- HSC Progenitor Proliferation · correlation 0.78
- Erythroid Maturation Signaling · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.