General Metabolic Housekeeping
Gene co-expression module in Hematopoietic progenitor cells
| Category | Housekeeping |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include zinc transporters (SLC39A3, SLC39A8), frataxin (FXN, mitochondrial iron-sulfur metabolism), NAA38 (N-terminal acetyltransferase), DTD1 (tRNA deacylase), ACSM3 (acyl-CoA synthetase), SERPINE2 (serine protease inhibitor), and EREG (EGF ligand). No single tight biological program unifies these genes; they represent diverse housekeeping metabolic functions expressed uniformly across HPC. Low mean expression and pct positive (19.3%) with core coherence suggests a constitutively expressed but low-level housekeeping module.
Genes
ACSM3, DTD1, EREG, FXN, NAA38, SERPINE2, SLC39A3, SLC39A8
Most correlated modules
- Biosynthetic Housekeeping · correlation 0.88
- Erythro-Megakaryocytic Development · correlation 0.87
- Oxidative Stress Survival · correlation 0.82
- Replication Stress Response · correlation 0.81
- HSC Progenitor Proliferation · correlation 0.79
- Erythroid Differentiation · correlation 0.78
- Chaperonin TRiC Complex · correlation 0.77
- Hematopoietic Progenitor Identity · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.