SH3BGRL — SH3 domain binding glutamate rich protein like

SH3BGRL belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SH3BGRL's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Oxidative Phosphorylation Mitochondrial & OxPhos	ATP5F1E, BLOC1S1, COX5B, COX6A1, COX6C, COX8A, DYNLRB1, GMFG +6 more	View in SCUBA
Fibroblasts	Notch Fibroblast Activation Developmental	CORO1C, DIXDC1, DSTN, FHL1, MRGPRF, PDLIM5, RBPJ, TCEAL3 +2 more	View in SCUBA
Gamma-delta T cells	Protein Homeostasis Chaperones Housekeeping	ATXN10, DYNLRB1, GMFG, HIGD1A, NAA10, POLR2J, PPIA, PPIB +6 more
Glial cells	ER Membrane Homeostasis Neroprotection	GNAI2, KHDRBS3, LITAF, RTN4, SARAF, SBDS, SNCA, VAPA +1 more	View in SCUBA
Hematopoietic progenitor cells	Oxidative Stress Survival Stress	GMPR, KIFAP3, PIM1, RIPOR3, SOD2, STON2, TAFA2
Innate lymphoid cells	ILC1 Actin Motility Cytoskeleton & motility	ACAP1, ARHGDIB, CORO1A, DGCR6L, EVL, GPSM3, HEXA, LCK +14 more	View in SCUBA
Lymphatic endothelial	Oxidative Stress Protection Stress	ALDH2, ANAPC16, BCL7C, CAVIN2, CCL21, CD320, CRACR2B, FXYD6 +10 more	View in SCUBA
Mucosal-associated invariant T cell	Oxidative Stress Response Stress	CDC42EP3, CTU1, EXOSC5, GLRX, GNPDA1, HTATIP2, KRCC1, MLX +11 more
Smooth muscle cells	SMC contractile apparatus Contractility	ACTA2, ACTB, CALD1, CAV1, DSTN, MYL6, MYL9, PPP1R14A +2 more	View in SCUBA

About the gene

Synonyms	MGC117402
Chromosome	X: 81202102-81298547
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Plasma proteins, Predicted intracellular proteins

Function

Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs. May function as a ubiquitin ligase-substrate adapter. Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.