Chaperonin TRiC Complex
Gene co-expression module in Hematopoietic progenitor cells
| Category | Housekeeping |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
The module is dominated by multiple CCT/TRiC chaperonin complex subunits (CCT2, CCT3, CCT5, CCT6A) which fold tubulin and actin, alongside YBX1 (RNA-binding/stress), TPI1 (glycolysis), NDUFS5/VDAC1 (mitochondrial), NUDC and ARL2 (tubulin folding cofactor). The CCT complex is a core proteostasis machine for cytoskeletal protein folding, representing a housekeeping chaperone program expressed uniformly across cell types.
Genes
ARL2, CCDC85B, CCT2, CCT3, CCT5, CCT6A, GADD45GIP1, NDUFS5, NUDC, SSB, TPI1, VDAC1, YBX1
Most correlated modules
- Nucleotide Metabolism · correlation 0.95
- Proteostasis & OxPhos · correlation 0.94
- RNA Processing Housekeeping · correlation 0.90
- DNA Damage Repair · correlation 0.89
- Ribosome Biogenesis · correlation 0.85
- Biosynthetic Housekeeping · correlation 0.82
- Hematopoietic Progenitor Identity · correlation 0.78
- General Metabolic Housekeeping · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.