SLC39A8 — Solute carrier family 39 member 8
SLC39A8 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC39A8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Nuclear Pore Organization Housekeeping | AIDA, DHX8, H4C6, LARP1, LBR, MPRIP, MTR, NNT +14 more | |
| Hematopoietic progenitor cells | General Metabolic Housekeeping Housekeeping | ACSM3, DTD1, EREG, FXN, NAA38, SERPINE2, SLC39A3 | |
| Macrophages | Hypoxia Stress Response Stress | ACE, AMPD3, APP, ASPH, BCAT1, BEX3, BHLHE41, BNIP3 +34 more | View in SCUBA |
| Monocytes | SPP1+ Inflammatory Macrophage Inflammatory | DOCK4, DUSP4, FLT1, GPR137B, IL7R, INHBA, MMP14, NECTIN2 +6 more | View in SCUBA |
About the gene
| Synonyms | BIGM103 |
|---|---|
| Chromosome | 4: 102251080-102431258 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters |
| Biological process | Ion transport, Symport, Transport, Zinc transport |
Function
Electroneutral divalent metal cation:bicarbonate symporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis and immunity. Transports an electroneutral complex composed of a divalent metal cation and two bicarbonate anions or alternatively a bicarbonate and a selenite anion. Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient. Also imports cadmium a non- essential metal which is cytotoxic and carcinogenic. May also transport iron and cobalt through membranes. Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development. Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization. Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes. Protects, for instance, cells from injury and death at the onset of inflammation. By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (By similarity). Reclaims manganese from the bile at the apical membrane of hepatocytes, thereby regulating the activity of the manganese-dependent enzymes through the systemic levels of the nutrient. Also participates in manganese reabsorption in the proximal tubule of the kidney. By mediating the extracellular uptake of manganese by cells of the blood-brain barrier, may also play a role in the transport of the micronutrient to the brain. With manganese cellular uptake also participates in mitochondrial proper function. Finally, also probably functions intracellularly, translocating zinc from lysosome to cytosol to indirectly enhance the expression of specific genes during TCR- mediated T cell activation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.