Biosynthetic Housekeeping
Gene co-expression module in Hematopoietic progenitor cells
| Category | Housekeeping |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
This is the highest expressed module (mean 1.272, 56.7% pct positive), indicating broad housekeeping activity. Hub genes: HSP90AB1 (constitutive chaperone, protein quality control), LDHB (lactate dehydrogenase B, glycolysis/metabolic), IMPDH2 (inosine monophosphate dehydrogenase, purine synthesis, upregulated in proliferating cells), HNRNPA1 (RNA binding, splicing), EEF1B2 (translation elongation), SERPINB1 (serine protease inhibitor, granulocyte/neutrophil marker), PRSS57 (serine protease, neutrophil granule), RSL1D1 (ribosome biogenesis), BZW2 (translation), TIMM13 (mitochondrial import), RBM3 (RNA binding, cold-shock), FBL (rRNA methylation, ribosome biogenesis), CREG1 (cellular repressor of E1A-stimulated genes). The combination of chaperones, translational machinery, ribosome biogenesis, and metabolic enzymes at high expression reflects core housekeeping/biosynthetic activity, with a secondary myeloid flavor (SERPINB1, PRSS57) consistent with HPC myeloid bias.
Genes
BZW2, CHST12, CREG1, EEF1B2, FBL, HNRNPA1, HSP90AB1, IMPDH2, LDHB, MEST, PRSS57, RBM3, RSL1D1, SERPINB1, SLC25A6, TIMM13
Most correlated modules
- General Metabolic Housekeeping · correlation 0.88
- Chaperonin TRiC Complex · correlation 0.82
- Erythro-Megakaryocytic Development · correlation 0.81
- Metabolic Housekeeping · correlation 0.80
- Nucleotide Metabolism · correlation 0.79
- HSC Progenitor Proliferation · correlation 0.75
- Erythroid Glycolysis · correlation 0.75
- Hematopoietic Progenitor Identity · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.