T-cell Progenitor
Gene co-expression module in Hematopoietic progenitor cells
| Category | Lymphcyte development |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
TRBC1 (T-cell receptor beta constant region), SKAP1 (T-cell-specific signaling adaptor), LAG3 (immune checkpoint expressed on T and NK cells), and GATA3 (T-cell lineage TF) are definitive T-cell markers. UCHL1 (PGP9.5) is expressed in T-cells and neurons. HOXB5 can mark T-cell progenitors. In the HPC context, this module likely reflects early T-cell progenitors (ETPs) or contaminating mature T-cells co-isolated with HPCs. The presence of TRBC1 suggests some mature T-cell signal.
Genes
DSC2, GATA3, HOXB5, LAG3, MDK, OPTN, PTMS, SELENOP, SKAP1, TRBC1, UCHL1
Most correlated modules
- Interferon Stimulated · correlation 0.73
- Metabolic Housekeeping · correlation 0.67
- Cytokine Feedback Signaling · correlation 0.64
- HSC Stem Identity · correlation 0.63
- Granulocyte Commitment · correlation 0.49
- Erythroid Glycolysis · correlation 0.47
- Multipotent Progenitor State · correlation 0.40
- Cytoskeletal Remodeling · correlation 0.38
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.