Erythroid Glycolysis
Gene co-expression module in Hematopoietic progenitor cells
| Category | Erythropoietic |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes GYPC (glycophorin C, erythroid surface marker) and LMO2 (erythroid/hematopoietic TF) define erythroid identity, while ENO1, GAPDH, TKT, and PKM represent the glycolytic upregulation characteristic of erythroid differentiation. MAP7 and VAMP8 also associate with erythroid maturation. The combination of erythroid lineage markers and glycolytic enzymes is a hallmark of erythropoiesis.
Genes
CMBL, ENO1, GAPDH, GYPC, LMO2, LY6E, MAP7, NENF, PKM, RFLNB, TKT, VAMP8
Most correlated modules
- Metabolic Housekeeping · correlation 0.78
- Chaperonin TRiC Complex · correlation 0.75
- Biosynthetic Housekeeping · correlation 0.75
- Nucleotide Metabolism · correlation 0.72
- RNA Processing Housekeeping · correlation 0.69
- Granulocyte Commitment · correlation 0.69
- HSC Stem Identity · correlation 0.66
- Proteostasis & OxPhos · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.