SKAP1 — Src kinase associated phosphoprotein 1
SKAP1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SKAP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB feedback TCR/AP1/NFKb pathway | ADTRP, AKAP5, CDIP1, CDKN2A, CLEC7A, INPP1, MAP3K5, N4BP1 +8 more | View in SCUBA |
| Gamma-delta T cells | Actin-based Motility Cytoskeletal | APBB1IP, CD58, COMMD7, CORO1B, CTSD, EVL, FDFT1, HMOX2 +13 more | |
| Hematopoietic progenitor cells | T-cell Progenitor Lymphcyte development | DSC2, GATA3, HOXB5, LAG3, MDK, OPTN, PTMS, SELENOP +2 more | |
| Innate lymphoid cells | ILC Identity Program Differentiation | AHR, APOL4, ARHGEF12, BLVRA, CD300LF, CDK2AP2, CEP83, COL4A4 +29 more | View in SCUBA |
| Mucosal-associated invariant T cell | Calcium Signal Integration TCR Signaling | ANKRD44, ARB2A, CAMK2D, DOCK10, ELMO1, EXOC4, FCHSD2, FNDC3A +20 more | |
| Natural Killer cells | Resident NK cells Gut residency | ANXA11, APBB1IP, CD151, CXXC5, HMOX2, LSP1, MPG, PPDPF +4 more | View in SCUBA |
About the gene
| Synonyms | SCAP1, SKAP55 |
|---|---|
| Chromosome | 17: 48133442-48430275 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Adaptive immunity, Immunity |
Function
Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T- cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.