Metabolic Housekeeping
Gene co-expression module in Hematopoietic progenitor cells
| Category | Housekeeping |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Core-coherent module with metabolic housekeeping enzymes: PPA1 (pyrophosphatase), TALDO1 (pentose phosphate pathway), PCBD1 (cofactor recycling), HINT1 (purine metabolism), EBPL (sterol biosynthesis), HSPB1 (chaperone), LSM7 (RNA splicing), YBX3 (general transcription). No lineage-specific markers; uniformly expressed. Represents constitutive metabolic and housekeeping programs. Neighbor M2 also has metabolic genes (glycolysis) supporting a metabolic neighborhood.
Genes
CRYGD, EBPL, HINT1, HSPB1, LSM7, PCBD1, PPA1, TALDO1, YBX3
Most correlated modules
- Biosynthetic Housekeeping · correlation 0.80
- Erythroid Glycolysis · correlation 0.78
- Granulocyte Commitment · correlation 0.75
- RNA Processing Housekeeping · correlation 0.72
- Interferon Stimulated · correlation 0.70
- Nucleotide Metabolism · correlation 0.68
- HSC Stem Identity · correlation 0.67
- T-cell Progenitor · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.