Interferon Stimulated
Gene co-expression module in Hematopoietic progenitor cells
| Category | Inflammatory |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
IFITM3 and BST2 are canonical interferon-stimulated genes (ISGs). PRDX1 defends against ROS, often co-induced with interferon responses. NPDC1 and EGFL7 mark hematopoietic progenitor identity. VAMP5 and MGST3 are stress-related. The module reflects an interferon-stimulated state in progenitor cells. Neighbor context (progenitor-rich neighborhood) supports an ISG program in HPCs.
Genes
BST2, EGFL7, IFITM3, LKAAEAR1, MGST3, NPDC1, PRDX1, VAMP5
Most correlated modules
- T-cell Progenitor · correlation 0.73
- Metabolic Housekeeping · correlation 0.70
- Erythroid Glycolysis · correlation 0.64
- HSC Stem Identity · correlation 0.60
- Multipotent Progenitor State · correlation 0.59
- Granulocyte Commitment · correlation 0.58
- Cytokine Feedback Signaling · correlation 0.54
- Quiescent HSC State · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.