DNA Damage Repair
Gene co-expression module in Hematopoietic progenitor cells
| Category | Housekeeping |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
The top hub genes are PRKDC (DNA-dependent protein kinase catalytic subunit, NHEJ DNA repair), PARP1 (poly-ADP ribose polymerase, DNA damage sensor/repair), and MSH6 (mismatch repair). SUPT16H encodes the FACT complex large subunit (chromatin remodeling enabling DNA repair/replication), NCL (nucleolin, DNA damage response and rRNA), HNRNPR (RNA processing), LARS1 (aminoacyl-tRNA synthetase), GSPT1 (eRF3, translation termination). The module is anchored by a DNA repair/genome integrity program.
Genes
GSPT1, HNRNPR, LARS1, MSH6, NCL, PARP1, PRKDC, SUPT16H
Most correlated modules
- Ribosome Biogenesis · correlation 0.93
- Chaperonin TRiC Complex · correlation 0.89
- Proteostasis & OxPhos · correlation 0.84
- Chromatin Remodeling · correlation 0.83
- Nucleotide Metabolism · correlation 0.83
- S-phase Progression · correlation 0.83
- RNA Processing Housekeeping · correlation 0.80
- Replication Stress Response · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.