Nucleotide Metabolism
Gene co-expression module in Hematopoietic progenitor cells
| Category | Housekeeping |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include MRPL12 (mitochondrial ribosomal protein), NME4 (mitochondrial nucleoside diphosphate kinase), GCSH (glycine cleavage, mitochondrial), SRM (spermidine synthase, nucleotide/polyamine metabolism), DNPH1/DCTPP1 (nucleotide catabolism), EIF4EBP1 (translation control), SNRPB (spliceosome), NHP2 (H/ACA snoRNP, ribosome biogenesis). The module reflects general nucleotide metabolism and mitochondrial/RNA housekeeping functions uniformly expressed.
Genes
DCTPP1, DNPH1, EIF4EBP1, FKBP4, GCSH, METTL26, MRPL12, NHP2, NME4, SNRPB, SRM
Most correlated modules
- Chaperonin TRiC Complex · correlation 0.95
- RNA Processing Housekeeping · correlation 0.93
- Proteostasis & OxPhos · correlation 0.92
- Ribosome Biogenesis · correlation 0.85
- DNA Damage Repair · correlation 0.83
- DNA Replication S-phase · correlation 0.82
- Biosynthetic Housekeeping · correlation 0.79
- Erythroid Heme Synthesis · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.