RNA Processing Housekeeping
Gene co-expression module in Hematopoietic progenitor cells
| Category | Housekeeping |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 15 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include SNRPD1/SNRPF/SNRPE (snRNP/spliceosome components), RAN/RANBP1 (nuclear transport), CDK4 (cell cycle kinase), HSPE1 (chaperonin), NME1 (nucleoside diphosphate kinase), DUT (deoxyuridine triphosphatase), NDUFAF8 (mitochondrial complex I assembly), ATP5MC1 (ATP synthase subunit), STOML2 (mitochondrial inner membrane), PSMG1 (proteasome assembly), C1QBP (mitochondrial ribosome), FABP5 (fatty acid binding), PDCD5 (apoptosis). This module blends housekeeping biosynthetic programs: RNA splicing, nuclear transport, mitochondrial function, and basic metabolic machinery. The uniform expression across all subsets and moderate-low pct positive (32.5%) is consistent with a broadly active housekeeping/proliferative support program rather than a single tight pathway. Compared to neighbors M67/M66/M35/M15/M64/M17 which are clearly cell-cycle-phase-specific, M43 represents more generalized cellular biosynthetic/housekeeping activity with some cell-cycle-entry genes (CDK4).
Genes
ATP5MC1, C1QBP, CDK4, DUT, FABP5, HSPE1, LSM5, NDUFAF8, NME1, PDCD5, PSMG1, RAN, RANBP1, SNRPD1, SNRPE, SNRPF, STOML2
Most correlated modules
- Nucleotide Metabolism · correlation 0.93
- Proteostasis & OxPhos · correlation 0.93
- Chaperonin TRiC Complex · correlation 0.90
- DNA Replication S-phase · correlation 0.86
- DNA Damage Repair · correlation 0.80
- Mitotic Spindle Checkpoint · correlation 0.78
- Ribosome Biogenesis · correlation 0.77
- S-phase Progression · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.