Proteostasis & OxPhos
Gene co-expression module in Hematopoietic progenitor cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
EIF5A (translation elongation factor, hypusination-dependent), COX5A (cytochrome c oxidase subunit, complex IV), NDUFB6 (NADH:ubiquinone oxidoreductase, complex I), MRPS34 (mitochondrial ribosomal protein), PSMB5 (proteasome beta-5 subunit, chymotrypsin-like activity), HSPA8 (Hsp70 chaperone), ILF2/HNRNPF/SLBP (RNA processing). As a neighbor to M12 and M6, this module reflects a mixed housekeeping program spanning mitochondrial respiration, translation, and proteostasis.
Genes
COX5A, EIF5A, HNRNPF, HSPA8, ILF2, MRPS34, NDUFB6, PSMB5, SLBP
Most correlated modules
- Chaperonin TRiC Complex · correlation 0.94
- RNA Processing Housekeeping · correlation 0.93
- Nucleotide Metabolism · correlation 0.92
- DNA Damage Repair · correlation 0.84
- DNA Replication S-phase · correlation 0.82
- S-phase Progression · correlation 0.79
- ER Protein Folding · correlation 0.79
- Ribosome Biogenesis · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.