SUPT16H — SPT16 homolog, facilitates chromatin remodeling subunit
SUPT16H belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SUPT16H's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Epigenetic Chromatin Maintenance DNA/chromatin regulation | BAZ1B, DDX46, DNMT1, HNRNPAB, NASP, NOP56, SET, SMC1A +2 more | View in SCUBA |
| Gamma-delta T cells | Mitotic Spindle Cell cycle | CAPRIN1, CDK5RAP2, CKAP5, CNTRL, DEK, DNMT1, FAM111A, GMPS +11 more | |
| Goblet cells | Chromatin Remodeling Repair chromatin regulation & transcription | CBX5, HACD3, NAP1L1, PARP1, PPM1G, PRKDC, PSIP1, SMC1A +1 more | View in SCUBA |
| Hematopoietic progenitor cells | DNA Damage Repair Housekeeping | GSPT1, HNRNPR, LARS1, MSH6, NCL, PARP1, PRKDC | |
| Macrophages | Replication Chromatin Assembly Cell cycle | ANP32B, CBX3, CDK4, COPS3, DEK, DNMT1, EMC8, EXOSC8 +22 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Remodeling DNA/chromatin regulation | BAZ2B, C1RL, CD2AP, GIT2, KIF5B, MIA2, RIF1, SPAG9 +1 more |
About the gene
| Synonyms | CDC68, FACT, FACTP140, FLJ10857, FLJ14010, SPT16/CDC68 |
|---|---|
| Chromosome | 14: 21351476-21384019 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Biological process | DNA damage, DNA repair, DNA replication, Host-virus interaction, Transcription, Transcription regulation |
Function
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.