Ribosome Biogenesis
Gene co-expression module in Hematopoietic progenitor cells
| Category | Housekeeping |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
DDX21 (DEAD-box helicase involved in rRNA processing), DKC1 (dyskerin, pseudouridine synthase for rRNA/snoRNP), NOP56/NOP58 (box C/D snoRNP components), NOLC1 (nucleolar and coiled body phosphoprotein), WDR43 (U3 snoRNA-associated, ribosome biogenesis), GNL3 (nucleostemin, nucleolar GTPase), PA2G4 (ErbB3-binding protein / ribosome biogenesis factor), SERBP1 (RNA-binding, nucleolar), HNRNPAB (RNA binding), LRPPRC (RNA binding, mitochondrial). This is a tight nucleolar/ribosome biogenesis module.
Genes
DDX21, DKC1, GNL3, HNRNPAB, LRPPRC, NOLC1, NOP56, NOP58, PA2G4, SERBP1, WDR43
Most correlated modules
- DNA Damage Repair · correlation 0.93
- Chaperonin TRiC Complex · correlation 0.85
- Nucleotide Metabolism · correlation 0.85
- Chromatin Remodeling · correlation 0.81
- S-phase Progression · correlation 0.79
- Proteostasis & OxPhos · correlation 0.78
- Replication Stress Response · correlation 0.77
- RNA Processing Housekeeping · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.