S-phase Progression
Gene co-expression module in Hematopoietic progenitor cells
| Category | Cell cycle |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes SMC2 (condensin complex, chromosome condensation), LMNB1 (nuclear lamina, S/G2/M), ATAD5 (PCNA unloading, replication), RRM1 (ribonucleotide reductase, dNTP synthesis), DNMT1 (DNA methylation maintenance during replication), ATAD2 (chromatin remodeling, S phase), BRCA2 (homologous recombination, S/G2), FANCI (Fanconi anemia, replication fork protection), TMPO (nuclear lamina, mitosis), TUBB (tubulin, mitosis). This module represents S-phase through early mitosis: DNA replication, chromatin remodeling, and nuclear envelope dynamics. It is a neighbor to M66 (S-phase initiation) and M35/M17 (mitotic spindle), supporting a G1/S-to-G2/M transition identity.
Genes
ATAD2, ATAD5, BRCA2, DNMT1, FANCI, LMNB1, RRM1, SMC2, TMPO, TUBB
Most correlated modules
- DNA Replication S-phase · correlation 0.92
- Replication Origin Licensing · correlation 0.92
- Mitotic Spindle Checkpoint · correlation 0.88
- Late S-phase G2 Entry · correlation 0.86
- DNA Damage Repair · correlation 0.83
- Ribosome Biogenesis · correlation 0.79
- Proteostasis & OxPhos · correlation 0.79
- RNA Processing Housekeeping · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.